Ethnicity moderates the association between 5-HTTLPR and national suicide rates

Autor(en)

Anne Schild, Ingo Nader, Jakob Pietschnig, Martin Voracek

Abstrakt

The association between ethnicity, national suicide rates, and the functional serotonin transporter gene polymorphism (5-HTTLPR), under consideration of the role of economic indicators, national alcohol intake, and national happiness scores was analyzed with an ecologic analysis. Data on allelic frequencies of the short (s) allele from 38 countries from over 100,000 healthy screened or general population individuals were analyzed with multiple regression models. Allele frequency varied widely both within and across ethnicities and an ethnicity-based interaction between national suicide rates and 5-HTTLPR allele frequency was revealed with the s allele acting as protective factor in Caucasian and as a risk factor in non-Caucasian populations. This interaction effect underlines the importance of ethnicity as a moderating factor in the genetics of suicide.

Organisation(en)

Institut für Psychologie der Kognition, Emotion und Methoden

Journal

Archives of Suicide Research

Band

18

Seiten

1-13

Anzahl der Seiten

13

ISSN

1381-1118

DOI

https://doi.org/10.1080/13811118.2013.803447

Publikationsdatum

2014

Peer-reviewed

Ja

ÖFOS 2012

501021 Sozialpsychologie

Schlagwörter

ASJC Scopus Sachgebiete

Psychiatry and Mental health, Clinical Psychology

Sustainable Development Goals

SDG 3 – Gesundheit und Wohlergehen

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/9bafccb0-6a7d-4f27-8dad-804acca63345